Search results for "Rheumatoid arthritis"

showing 10 items of 209 documents

The Neuropsychological Profile of Infantile Duchenne Muscular Dystrophy

2011

It has been shown that children with Duchenne muscular dystrophy (DMD) exhibit specific cognitive deficits. However, the neuropsychological profile has not yet been fully characterized. In order to control for the contribution of motor impairments as a confounding variable that is usually present when assessing children with muscular pathologies, we compared children with DMD to a group of children with an autoimmune pathology that does not entail either brain or cognitive dysfunction but does imply motor impairment: juvenile rheumatoid arthritis (JRA). An extensive neuropsychological evaluation was administered, including intelligence, perception, language, memory and learning, attention, …

MaleDevelopmental DisabilitiesDuchenne muscular dystrophyIntelligenceNeuropsychological TestsPraxiJuvenile rheumatoid arthritiDevelopmental psychologySettore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'EducazioneExecutive FunctionDiscrimination PsychologicalDevelopmental and Educational PsychologyNeuropsychological assessmentMuscular dystrophyChildmedia_commonmedicine.diagnostic_testMedicine (all)NeuropsychologyPhonological analysiCognitionVerbal LearningPsychiatry and Mental healthClinical PsychologyMemory Short-TermNeuropsychology and Physiological PsychologyChild PreschoolNeuropsychological TestFemalePsychologyHumanClinical psychologyDuchenne muscular dystrophymusculoskeletal diseasesDevelopmental Disabilitiemedia_common.quotation_subjectVerbal learningNeuropsychological assessmentStatistics NonparametricCognition DisorderArts and Humanities (miscellaneous)PerceptionmedicineHumansDiscrimination (Psychology)Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamedicine.diseaseArthritis JuvenileMuscular Dystrophy DuchennePerceptionCognition DisordersJuvenile rheumatoid arthritis
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Risk for periodontal disease in patients with longstanding rheumatoid arthritis.

1998

Objective. To quantify periodontal disease in rheumatoid arthritis (RA) patients and controls, and to correlate the degree of destruction from periodontal disease and from RA Methods. Fifty RA patients were matched for age, sex, smoking status, and oral hygiene with 101 controls. Correlations between indices of chronic destruction in periodontal disease (gingival attachment loss) and in RA (Larsen radiographic score) were determined. Results. Patients with longstanding active RA (mean ± SD 13 ± 8 years) who were receiving treatment with disease-modifying antirheumatic drugs (n = 46), corticosteroids (n = 38), or nonsteroidal antiinflammatory drugs (n = 43) had a higher rate of gingival blee…

AdultMalemedicine.medical_specialtyOral Hygiene IndexImmunologyGingivaArthritisDentistryOral hygieneGastroenterologyArthritis RheumatoidRheumatologyRisk FactorsInternal medicineImmunopathologyOral and maxillofacial pathologymedicineImmunology and AllergyHumansPharmacology (medical)Risk factorArthrographyAgedAutoimmune diseasebusiness.industryMiddle Agedmedicine.diseaseOral HygieneClinical attachment lossRheumatoid arthritisGingival DiseasesDisease ProgressionFemaleJointsbusinessArthritis and rheumatism
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Anti-inflammatory Therapies for Cardiovascular Disease: Signaling Pathways and Mechanisms

2019

Cardiovascular diseases (CVD) are the clinical manifestation of atherosclerosis, a chronic inflammatory disease promoted by several risk factors such as dyslipidemia, type 2 diabetes mellitus, hypertension, and smoking. Acute CVD events are the result of an unresolved inflammatory chronic state that promotes the rupture of unstable plaque lesions. Of note, the existing intensive therapies modify risk factors but do not prevent life-threatening recurrent ischemic events in high-risk patients, who have a residual inflammatory risk displayed by increased C-reactive protein (CRP) levels. Better understanding of the role of innate and adaptive immunity in plaque development and rupture has led t…

Inflammationbusiness.industrymedicine.medical_treatmentAnti-Inflammatory AgentsType 2 Diabetes MellitusGeneral MedicineDisease030204 cardiovascular system & hematologymedicine.diseaseBioinformaticsAcquired immune systemClinical trial03 medical and health sciencesC-Reactive Protein0302 clinical medicineCytokineCardiovascular DiseasesPsoriasisRheumatoid arthritismedicineHumansbusinessBiomarkersDyslipidemiaSignal TransductionRevista Española de Cardiología (English Edition)
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A10.8 Evaluation of Disease Activity in Adult Patients with Juvenile Idiopathic Arthritis

2013

Background Juvenile idiopathic arthritis (JIA) is a disease which maintains specific childish rheumatological features during whole life. There is still an open discussion which criteria of the disease activity should be used for the management of adult patients with JIA. Objectives To analyse the usefulness of known disease activity and functional indices used in adult rheumatological practise for the assessment of rheumatoid arthritis (RA) and spondyloarthritidies (SpA): disease acitivity score (DAS), disease acitivity score 28 (DAS28), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Spondylitis Functional Index (BASFI), Health Assessment Questionnaire – disability index…

musculoskeletal diseasesmedicine.medical_specialtyAnkylosing spondylitisbusiness.industryImmunologyArthritismedicine.diseaseConnective tissue diseaseGeneral Biochemistry Genetics and Molecular BiologyRheumatologyRheumatologyInternal medicineRheumatoid arthritismedicinePhysical therapyImmunology and Allergyskin and connective tissue diseasesbusinessBASFISpondylitisBASDAIAnnals of the Rheumatic Diseases
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Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)

2011

Introduction: Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to evaluate the safety and clinical outcomes of rituximab in several standard-of-care-refractory autoimmune diseases (within rheumatology, nephrology, dermatology and neurology) other than rheumatoid arthritis or non-Hodgkin's lymphoma in a real-life clinical setting. Methods: Patients who received rituximab having shown an inadequate response to standard-of-care had their safety and clinical outcomes data retrospectively analysed as part of the German Registry of Autoimmune…

AdultNephrologyrituximab; autoimmune diseasesmedicine.medical_specialtyHealth StatusImmunologyDrug ResistanceAutoimmune DiseasesDrug HypersensitivityAntibodies Monoclonal Murine-Derived03 medical and health sciences0302 clinical medicineRheumatologyimmune system diseaseshemic and lymphatic diseasesGermanyInternal medicinemedicineHumansImmunology and Allergyddc:610RegistriesRetrospective Studies030203 arthritis & rheumatologyAutoimmune diseasebusiness.industryRetrospective cohort studymedicine.diseaseRheumatology3. Good healthLymphomaPemphigusTreatment OutcomePatient SatisfactionAntirheumatic AgentsRheumatoid arthritisImmunologyRituximabRituximabbusinessImmunosuppressive Agents030217 neurology & neurosurgeryResearch ArticleFollow-Up Studiesmedicine.drugArthritis Research & Therapy
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Effect of nonsurgical periodontal treatment in patients with periodontitis and rheumatoid arthritis: a systematic review

2016

Background: Periodontitis has been regarded as a potential risk factor for rheumatoid arthritis (RA). A systematic review is made to determine whether nonsurgical periodontal treatment in patients with RA offers benefits in terms of the clinical activity and inflammatory markers of the disease. Material and Methods: A search was made of the Medline-PubMed, Cochrane, Embase and Scopus databases to identify studies on the relationship between the two disease processes, and especially on the effects of nonsurgical treatment in patients of this kind. The search was based on the following keywords: rheumatoid arthritis AND periodontitis (MeSH), rheumatoid arthritis AND periodontal treatment . Re…

musculoskeletal diseasesPeriodontal treatmentmedicine.medical_specialtyTerapéuticaDentistryArthritisOdontologíaReviewDiseaseArtritis reumatoideArthritis Rheumatoid03 medical and health sciencesTratamiento médico0302 clinical medicineInternal medicinemedicineHumansIn patientskin and connective tissue diseasesInterleukin 6PeriodontitisGeneral DentistryPeriodontal Diseases030203 arthritis & rheumatologyPeriodontitisbiologyInterleukin-6business.industryC-reactive protein030206 dentistryMedically compromised patients in Dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludC-Reactive ProteinOtorhinolaryngologyRheumatoid arthritisUNESCO::CIENCIAS MÉDICASbiology.proteinSurgerybusinessEnfermedad
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Evaluation of labial microvessels in Sjogren syndrome: A videocapillaroscopic study

2008

Summary Sjogren's syndrome (SS) is a chronic autoimmune rheumatic disease characterized by a progressive lymphocytic infiltration of exocrine glands, especially salivary and lachrymal ones, leading to xerostomia, parotid gland enlargement, and xerophtalmia. SS may occur alone (primary) or in association with almost any of the autoimmune rheumatic diseases (secondary), the most frequent being rheumatoid arthritis. The aim of this study is to describe the capillaroscopic pattern of the labial mucosa in patients with SS. Methods A total of 20 patients affected by SS and 20 healthy controls were examined. The patients with conditions that compromise microcirculation, such as diabetes, hypertens…

AdultMalePathologymedicine.medical_specialtyExocrine glandSjögren syndromeMicrocirculationArthritis Rheumatoidstomatognathic systemReference ValuesRheumatic DiseasesDiabetes mellitusHyperlipidemiamedicineHumansSjogren syndromeLabial MucosaLabialAgedParotid gland enlargementCapillaroscopybusiness.industryMicrocirculationPatient SelectionMouth MucosaGeneral MedicineMiddle Agedmedicine.diseaseCapillariesstomatognathic diseasesSjogren's Syndromemedicine.anatomical_structureRheumatoid arthritisFemaleAnatomybusinessAlgorithmsDevelopmental BiologyAnnals of Anatomy - Anatomischer Anzeiger
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Evidence for auto-reactivity against the collectins, SP-A and MBL, in rheumatoid arthritis synovial fluids: Lack of cross-reactivity with C1q or type…

1997

ChemistryRheumatoid arthritisImmunologyImmunologymedicineType II collagenImmunology and AllergyCollectinReactivity (chemistry)medicine.disease_causemedicine.diseaseCross-reactivityImmunology Letters
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Unterschiede im Erhaltungszustand zwischen vorderem und hinterem Kreuzband bei rheumatoider Arthritis

2008

In rheumatoid arthritis (RA) we examined the cruciate ligaments of 16 patients by the use of light- and transmission electron microscopy. Considerable differences between the anterior (ACL) and the posterior cruciate ligament (PCL) were observed. The ACL showed dramatic ultrastructural changes, against that the PCL was compact and well conserved. The preservation of PCL in joint surgery can morphologically be recommended. Perhaps the greater inflammatory process on the surface of ACL is responsible for the observed differences.

Joint surgerybusiness.industryAnterior cruciate ligamenttechnology industry and agriculturemacromolecular substancesAnatomyequipment and suppliesmusculoskeletal systemmedicine.diseaseLower limbmedicine.anatomical_structurePosterior cruciate ligamentRheumatoid arthritismedicineOrthopedics and Sports MedicineSurgeryNuclear medicinebusinesshuman activitiesZeitschrift für Orthopädie und ihre Grenzgebiete
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